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A plasmonic nanohole sensor for virus‐like particle capture and virucidal drug evaluation is reported. Using a materials‐selective surface functionalization scheme, passive immobilization of virus‐like particles only within the nanoholes is achieved. The findings demonstrate that a low surface coverage of particles only inside the functionalized nanoholes significantly improves nanoplasmonic sensing...
Recently, targeted delivery systems based on functionalized polymeric nanoparticles have attracted a great deal of attention in cancer diagnosis and therapy. Specifically, as neuroblastoma occurs in infancy and childhood, targeted delivery may be critical to reduce the side effects that can occur with conventional approaches, as well as to achieve precise diagnosis and efficient therapy. Thus, biocompatible...
There is an emerging need for portable, robust, inexpensive, and easy‐to‐use disease diagnosis and prognosis monitoring platforms to share health information at the point‐of‐living, including clinical and home settings. Recent advances in digital health technologies have improved early diagnosis, drug treatment, and personalized medicine. Smartphones with high‐resolution cameras and high data processing...
Control over neurite orientation in primary hippocampal neurons is achieved by using interrupted, anisotropic micropillar arrays as a cell culture platform. Both neurite orientation and neurite length are controlled by a function of interpillar distance.
Upon PEG removal, the change of rod shapes into globule shapes is observed for packaged DNA in polyplex micelles that are prepared from block copolymers with acid‐labile linkage between the PEG and poly(L‐lysine) (PLys). On page 1193, K. Osada, K. Kataoka, and co‐workers use the details of this transition behavior to elucidate the essential regulating factors of polyplex micelle structures, in order...
Neurons, like most cells, exhibit strong morphological responses to the physical features of their environment, and topographical structures are often utilized to elicit unique neuronal behavior. On page 1148, I. S. Choi and co‐workers demonstrate directional control over the neurites of primary hippocampal neurons by using anisotropic pillar topographies as a culture platform. The relationship between...
A novel protein recognition platform is developed using aptamer‐linked polythiophene nanowires. As the aptamer functionalized poly (3‐methylthiophene) nanowire is treated by the specific protein, resonance Raman and photoluminescence signals are simultaneously enhanced. Statistical analyses deliver the capability of a single conjugated polymer nanowire with phase‐transition characteristics in response...
Nanoparticles prefer to bind to a membrane with a surface coated by short or rigid ligands, as shown by computer simulations. To realize such a preferred configuration, the nanoparticle can spontaneously spin itself on the membrane surface, no matter what its initial orientation is.
The surprisingly spontaneous rotation behavior of nanoparticles whose surfaces are coated by two types of different ligands on the cell membrane surfaces are found by K. Yang, Y.‐Q. Ma, and co‐workers using computer simulations. As shown on page 1140 and illustrated in the lovely front cover of this special issue, such rotations of nanoparticles, and the final preferred configurations of nanoparticles...
In nature, pollen grains play a vital role for encapsulation. Many pollen species exist which are often used as human food supplements. Dynamic image particle analysis, scanning electron microscopy, and confocal microscopy analysis confirmed the size, structural uniformity, and macromolecular encapsulation in sunflower pollen, paving the way to explore natural pollen grains for the encapsulation of...
The ultimate goal in the area of drug‐delivery systems is the development of a nanoparticle that can penetrate the endothelial cell monolayer for the targeting of tissue parenchyma. In the present study, we identify a transcytosis‐targeting peptide (TTP) that permits polyethyleneglycol (PEG)‐modified liposomes (PEG‐LPs) to penetrate through monolayers of brain‐derived endothelial cells. These endothelial...
A spatiotemporally controllable gene delivery carrier is developed using a polymer‐conjugated, single layered MoS2 nanocomposite by W. J. Kim and co‐workers on page 1184. When subjected to near infrared light, the photothermal effect of MoS2 induces the endosomal escape of nanocomposite, thereby transferring it into the cytosol. Subsequently, intracellular redox conditions release the polymers from...
Nanomedicine has been growing exponentially due to its enhanced drug targeting and reduced drug toxicity. It uses the interactions where nanotechnological components and biological systems communicate with each other to facilitate the delivery performance. At this scale, the physiochemical properties of delivery systems strongly affect their capacities. Among current delivery systems, DNA nanotechnology...
The role of poly(ethylene‐glycol) (PEG) in rod‐shaped polyplex micelle structures, having a characteristic core of folded plasmid DNA (pDNA) and a shell of tethered PEG chains, is investigated using PEG‐detachable polyplex micelles. Rod shapes undergo change to compacted globule shapes by removal of PEG from polyplex micelles prepared from block copolymer with acid‐labile linkage between PEG and poly(l‐lysine)...
Stimuli‐responsive gene delivery systems maximize therapeutic efficacy by controlling the cytosolic conveyance and rate of effective gene release. We present herein a hybrid nanocomposite composed of a 2D nanomaterial, MoS2, modified by attaching two polymers (polyethylenimine (PEI) and polyethylenglycol (PEG)) via disulfide bonds. This MoS2–PEI–PEG nanocomposite interacts with DNA by electrostatic...
For tissue engineering applications, it is important to develop fabrication strategies for building models with controlled cell distributions in defined structures. Here, a simple, flexible approach (named the μ‐eraser strategy) is developed to construct multicell micropatterns. This approach involves pressing a poly(dimethylsiloxane) stamp to erase cells growing on substrates, and seeding other types...
At the nano–bio interface, human plasma differentially interacts with engineered nanomaterials through the creation of protein coronas, which in turn become primary determinants of both the pharmacokinetics and pharmacodynamics of circulating nanoparticles. Here, for the first time, the specific binding kinetics of the four major corona forming proteins (human serum albumin, fibrinogen, ApoA1, and...
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